ชื่อเรื่อง : Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan

ชื่อผู้แต่ง : Xiaochen Li, Shuyun Xu, Muqing Yu, Ke Wang, Yu Tao, Ying Zhou, Jing Shi, Min Zhou, Bo Wu, Zhenyu Yang, Cong Zhang, Junqing Yue, Zhiguo Zhang, Harald Renz, Xiansheng Liu, Jungang Xie, Min Xie, Jianping Zhao

สำนักพิมพ์ : ELSEVIER

เนื้อหาโดยย่อ : Abstract: Background
In December 2019, COVID-19 outbreak occurred in Wuhan. Data on the clinical characteristics and outcomes of patients with severe COVID-19 are limited.
Objective
The severity on admission, complications, treatment, and outcomes of COVID-19 patients were evaluated.
Methods
Patients with COVID-19 admitted to Tongji Hospital from January 26, 2020 to February 5, 2020 were retrospectively enrolled and followed-up until March 3, 2020. Potential risk factors for severe COVID-19 were analyzed by a multivariable binary logistic model. Cox proportional hazard regression model was used for survival analysis in severe patients.
Results
We identified 269 (49.1%) of 548 patients as severe cases on admission. Elder age, underlying hypertension, high cytokine levels (IL-2R, IL-6, IL-10, and TNF-a), and high LDH level were significantly associated with severe COVID-19 on admission. The prevalence of asthma in COVID-19 patients was 0.9%, markedly lower than that in the adult population of Wuhan. The estimated mortality was 1.1% in nonsevere patients and 32.5% in severe cases during the average 32 days of follow-up period. Survival analysis revealed that male, elder age, leukocytosis, high LDH level, cardiac injury, hyperglycemia, and high-dose corticosteroid use were associated with death in patients with severe COVID-19.
Conclusions
Patients with elder age, hypertension, and high LDH level need careful observation and early intervention to prevent the potential development of severe COVID-19. Severe male patients with heart injury, hyperglycemia, and high-dose corticosteroid use may have high risk of death.

Link : Full Text